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The Lee-Benner Institute is offering Fellowship positions to outstanding candidates who have a strong career interest in Antiaging Medicine. These unique two year training programs are under the direction and personal supervision of Lord Lee-Benner, M.D., F.A.C.E.
Earn 100 Category 1 American Medical Association Continuing Medical Education (CME) Credits.
Dr. Lee-Benners credentials (C.V.) can be viewed at www.theantiagingdoctor.com
Reinventing Your Clinical Practice
To Meet the Challenges Facing Medical Practitioners Today
Lee-Benner Institute Two Year Fellowship Program
This prestigious program begins with a high caliber, intensive one week course in theArt and Science of Antiaging Medicine at Newport Beach, CA. The candidates then will return to their own practice area for the two year supervisory period. Candidates who successfully present longitudinal studies and clinical data on 10 of their own patients at the end of the two year period will be awarded the honor of being appointed a Fellow of the LBI for Antiaging Medicine. The successful candidate will receive a Certificate of satisfactory completion of the 2 years fellowship program attesting they have been accepted and inducted as a Clinical Fellow of the Lee-Benner Institute for Antiaging Medicine with full honors and privileges thereof.
The initial one week period consists of 5 days formal instruction. Two additional days are included so that further questions to Dr. Lee-Benner or clarifications can be made. During that time, Dr. Lee-Benner will invite the candidate for a casual round of golf at a local course, and on the other day, weather and time permitting, Dr. Lee-Benner will invite the candidate to be a guest aboard his yacht for a cruise of the Newport Harbor and Southern California Coastline.
ACertificate certifying satisfactory completion of the one week intensive course in the Art and Science of Antiaging Medicine and acceptance as a Candidate for the Clinical Fellowship will be presented at that time.
Course Name: Clinical Interventions for the Changes Related to Aging
Part One: Introduction to Clinical Interventions"The Lee-Benner Method"
Lectures and Hands On-Experiencing
Part Two: Basic Science Review
I. Biochemistry with Clinical Correlations
1. Structure of macromolecules
2. Transmission of information
3. Functions of proteins
4. Metabolic pathways and their control
5. Physiological processes
II. Biology of Aging
1. Free radicals in Medicine and Biology
2. Mitochondrial actions; interactions
3. DNA/RNA mutations
4. Replicative senesence and telomere shortening
5. Differences between aging and disease
6. Post-reproductive dissociation of integrated change
7. Age-related, rates of decline in various physiologic functions
8. Temporal relationships associated with cyclic reproductive function
9. Physiologic dysfunction, temporal disorder and pathology relationships
10. Growth Hormone Deficiency (GHD)
11. Consequences of dysfunctional GH neuroendocrine axis
12. Pituitary dynamic tests and aging
13. Melatonin decline with aging
14. The Adrenal Gland
15. Age-related DHEA-S decline
16. The testes
17. Testosterone response to hGH
18. Pituitary response to LHRH
19. The ovary
20. Age-related bio-LH iso-electric-focusing profile changes in women
21. The Thyroid
22. TSH response with aging
23. The Pancreas
24. Oral glucose tolerance test (OGTT) in non-obese healthy males
25. GH Neuroendocrine-axis
26. Regulation of GH secretion
27. Neuroendocrine change with aging
28. GH secretion throughout life
29. The decline of GH with aging-mechanisms
30. Is age-related frailty an endocrine deficiency state?
31. Functional ability with age
Caloric Restrictions (CR)
Growth Hormone (GH)
Insulin-like Growth Factor (IGF-I)
GHRH; GH secretagogues (ghrelin mimetics)
33. Adult GH deficiencya model and a precedent
34. GH for normal aging: first reports
35. Chronic IGF-I ± GH treatment
36. Potential for GHRH as intervention therapy
37. What did we know previously?
38. What dont we know now?
39. What should we do in the future?
Part Three:Neurobiology of Growth Hormone Deficiency and Aging
I Historical and Current Perspectives
Nomenclature and early sources
Initiatives for testing GH efficacy in the elderly
Clinical similarities between GHD and Aging
Different replacement modalities: end product vs. secretagogues
II Complementary Interventions
Exercise and diet
Gender differences to physical activity
Chronic activity related to age and hormone replacement
Testosterone, estrogen and other sex hormones
III Effects on Systems Physiology (Bone and Muscle)
Markers for bone density
Differential effects of GHD onset on bone mineralization
Temporal relationships between treatment onset and bone formation
Lean Body Mass effects
Different effects on body loci
IV Effects on Systems Physiology (Immunity)
Organ sensitivity to hormone influence
Relationship between thymopoiesis and disease
Effect of GH on immune system cell types
Toxicity and plieotrophic effects on T cell recovery
Mechanism for promoting thymopoiesis
V Secretagogue Therapy
Effect of GHRH on body composition
Influence of Estrogen
Production of loci for endogenous GHRPs
Mechanism of GH releasing action
Role of Somatostatin
Atypical effects of GH secretagogues
Effects on fluid retention, arthralgias, carbohydrate metabolism, etc.
Age relationship to toxicity
Dosage relationships to risk
Natural conditions; acromegaly
Methods for measuring GH hyper-secretion
VII Ethical and Regulatory Issues
Risk benefit in healthy aging persons
Federal restrictions against "off label" use of hGH
Moral dilemma in treating healthy patients
Art of medicine and authority to treat
Research vs. Therapy
Informed consent in investigational processes
Part Four: Clinical Issues for the Regulation of Physiological Changes During Adult Human Aging.
The following content contains clinical practice guidelines for determining the most effective methods of diagnosing and treating these critical factors that affect adult human aging. These guidelines are a working document that reflects the state of the field at the time of presentation. Because rapid changes in all of these areas are expected, periodic revisions will be inevitable. The present recommendations may not be appropriate in all situations. Also, any decision by practitioners to apply these guidelines must be made in the context of local resources and individual patient circumstances.
Recommended Textbooks, and Study Guides
for the LBI Fellowship Program
Physicians Guide to Free Radicals, Immunity and Aging. Lee-Benner, Lord, World Health Foundation Press, Newport Beach, CA., 1990
Physicians Guide to Physical Fitness. Lee-Benner, Lord, World Health Foundation Press, Newport Beach, CA., 1996
Turning Back the Aging Clock. Lee-Benner, Lord, World Health Foundation Press, Newport Beach, CA., 1997
Textbook of Biochemistry with Clinical Correlations, Fifth Edition. Devlin, Thomas, Editor, Wiley-Liss, New York, 2002
Basic Neurochemistry, Fifth Edition. Siegel, Geo, Agranoff, Bernard, Alber, Wayne, Molinoff, Perry, Editors. Raven Press, N.Y., 1994
Neuroendocrinology in Physiology and Medicine. Conn, P Michael, freeman, Marc, Editors, Humana Press, Totowa, New Jersey, 2000
Endocrinology, Fourth Edition (3 Vols.) DeGroot, Leslie, Jameson J. Larry, Editors. W.B. Saunders, Phila., PA., 2001
Users Guides to the Medical Literature, a Manual for Evidence-Based Clinical Practice. Guyatt, Gordan, Renme, Drummond, Editors. AMA Press, 2002
Guidelines for Exercise Testing and Prescription, Third Edition. American College of Sports Medicine, Lea & Febiger, Phila., 1986
The Heart Rate Monitor, Edwards, Sally, Fleet Feet Express, Sacramento, CA., 1997
Training Lactate Pulse-Rate. Janssen, Peter, Polar Electro Oy Pubs, Finland 1987
Practical Handbook of Human Biologic Age Determination. Balin, Arthur, CRC Press, Boca Raton, FL., 1994
Biological Aging Measurements, Clinical Applications. Dean, Ward. The Center for Biogerontology, Pensacola, Fl., 1988
Growth Hormone in Adults, Physiological and Clinical Aspects, Second Edition. Juul, Anders, Jorgensen, Jens, Editors, Cambridge University Press, U.K., 2000
The Biology of Aging. Brookbank, John, Harper & Row Press, N.Y., 1660
The Potential for Nutritional Modulation of Aging Process. Ingram, Donald, Baker, Geo., Shock, Nathan, American Health Foundation Food & Nutrition Press, Trumbull, Conn. 1988
U.S. Department of Agriculture Composition of Foods, Handbook No. 8, USDA, Washington, D.C.
Endocrinology of Aging. Morley, John, Van den Berg, Lucretia, Editors, Humana Press, Totowa, New Jersey, 2000
Hormones, Gender and the Aging Brain, the Endocrine Basis of Geriatric Psychiatry. Morrison, Mary, Editor, Cambridge Univ. Press, U.K., 2000
Aging and Male Sexuality. Schiavi, Raul, Cambridge Unive. Press, U.K., 1999
Science, published weekly by the American Association for the Advancement of Science, Wash., D.C.
Nature Medicine, published monthly by Nature Publishing Group, N.Y.
Endocrine Practice, published six times a year; the official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, Jacksonville, Fl., www.aace.com
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