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BIG BLUE DOUBLE-MUSCLE SYNDROME |
E-Newsletter No. 4
A specific gene has been found that limits the size of skeletal muscles. This size effect appears to be exclusively from skeletal muscle. All other cells are unaffected. The gene produces a protein called myostatin. This protein is secreted in the part of the embryo that controls skeletal muscle. It is also found in the muscles of adult mammals. These act like hormones as there are specific receptors for them on the cell wall outer membranes.
Click here to learn more about myostatin
Over the past 30 years, the farmers in Belgium have bred a strain of cattle - The mighty Belgium Blue - that gives 20% more meat per animal on roughly the same food intake as ordinary animals. Indeed, the cattle develop such bulging muscles that in extreme cases, they have to be delivered by cesarean section. This "double muscling trait" had been reported as early as 1807.
Genetic Mutation
In the September issue of Nature Genetics, a European research team
reports that double muscling is caused by a mutation in the bovine version of the recently
discovered gene that makes the protein called myostatin. In the U.S., two other groups,
one from the U.S. Department of Agriculture, and the other from John Hopkins University,
reported in September issue of Genome Research and in the Proceedings of the
National Academy of Sciences, that the myostatin gene is mutated in Belgium Blues and
have linked mutations in the gene to double muscling in a second breed of cattle, the
Piedmontese, as well.
How does Myostatin work?
Discovered in mice just four months ago, myostatin normally serves to limit skeletal
muscle growth. Apparently, the genetic mutations block its activity in limiting
muscle growth. The animals muscles grow larger-but without harming meat quality.
The muscles of animals with the myostatin genetic mutations have been discovered to have larger
numbers of normal-size fibers. Nevertheless, the meat of the cattle is "so
tender, even round steaks fall apart on the grill". It is also lower in fat
than that from ordinary breeds.
Lee-Benner Institute Research
Here at the Lee-Benner Institute, we have been working with a group of protein
chemists who are developing peptide analogues (short chains of amino acids). These
analogues, combined with vitamin co-factors, function as enzyme inhibitors that interfere
with the growth limiting action of the myostatin protein. These analogues might be useful
in treating muscle-wasting diseases. In mice, the effects of inactivating the gene
has increased muscle-cell number by 86%. Most of the muscle growth in adult
humans, for example, whether from weight-training or steroids, is caused by hypertrophy
(increasing the size of the muscle cell), not hyperplasia (increasing the number of
muscle cells).
Peptide Analogues and the brain
Another aspect of these peptide analogues is that they seem to impart many of their
actions in the brain. When they are injected into frail, elderly adult humans, there
appears to be an increase in drive, energy, motivation, and overall improvement in
complex mental functions such as memory, concentration, comprehension, calculation.
Even balance and coordination are improved. We are currently studying the effects on
strength and stamina in humans. Keep watching this newsletter for future updates on these
and other exciting developments in Anti-Aging research.
Also see:
Sarcopenia -- The Role of Mitochondrial DNA (mt DNA) Deletion Mutation
Myoplex® Effectiveness For Sarcopenia of Aging
Muscle Builder Myoplex®Induces Il-4